Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

Author:

Patacq Clément12,Chaudet Nicolas2,Létisse Fabien1ORCID

Affiliation:

1. TBI, Université de Toulouse, INSA, INRAE, CNRS, UPS, Toulouse, France

2. Sanofi Pasteur, Département de Bioprocédés R&D, Marcy-l’Etoile, France

Abstract

The capacity of microbes to resist and overcome environmental insults, known as resilience, allows them to survive in changing environments but also to resist antibiotic and biocide treatments and immune system responses. Although the role of the stringent response in bacterial resilience to nutritional stresses has been well studied, little is known about its importance in the ability of the bacteria to not just resist but also recover from these disturbances.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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