Computational Modeling of Macrophage Iron Sequestration during Host Defense against Aspergillus-Reference-Cited by-同舟云学术

Computational Modeling of Macrophage Iron Sequestration during Host Defense against Aspergillus

Published:2022-08-31 Issue:4 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Adhikari Bandita¹²,Scindia Yogesh³,Sordo Vieira Luis³,de Assis Lopes Ribeiro Henrique³,Masison Joseph²,Yang Ning³,Fonseca Luis L.³,Wheeler Matthew³,Knapp Adam C.³,Mei Yu³,Helba Brian⁴,Atkinson Carl³,Schroeder Will⁴,Mehrad Borna³,Laubenbacher Reinhard³^ORCID

Affiliation:

1. University of Pennsylvania, Philadelphia, Pennsylvania, USA

2. Center for Quantitative Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA

3. University of Florida, Gainesville, Florida, USA

4. Kitware Inc., Albany, New York, USA

Abstract

Invasive pulmonary aspergillosis is a major cause of death among immunosuppressed individuals despite the best available therapy. Depriving the pathogen of iron is an essential component of host defense in this infection, but the mechanisms by which the host achieves this are complex.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00074-22

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