Phage Resistance Accompanies Reduced Fitness of Uropathogenic Escherichia coli in the Urinary Environment-Reference-Cited by-同舟云学术

Phage Resistance Accompanies Reduced Fitness of Uropathogenic Escherichia coli in the Urinary Environment

Published:2022-08-31 Issue:4 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Zulk Jacob J.¹,Clark Justin R.¹,Ottinger Samantha¹,Ballard Mallory B.¹,Mejia Marlyd E.¹,Mercado-Evans Vicki¹²,Heckmann Emmaline R.¹,Sanchez Belkys C.¹^ORCID,Trautner Barbara W.³⁴,Maresso Anthony W.¹,Patras Kathryn A.¹⁵^ORCID

Affiliation:

1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

2. Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, USA

3. Center for Innovations in Quality, Effectiveness, and Safety (IQuESt), Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA

4. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

5. Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, Texas, USA

Abstract

UTI is one of the most common causes of outpatient antibiotic use, and rising antibiotic resistance threatens the ability to control UTI unless alternative treatments are developed. Bacteriophage (phage) therapy is gaining renewed interest; however, much like with antibiotics, bacteria can readily become resistant to phages.

Funder

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00345-22

Reference98 articles.

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