Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease-Reference-Cited by-同舟云学术

Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

Published:2020-12-23 Issue:6 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Rule Chelsea S.¹,Park Young-Jun²,Delarosa Jaclyn R.²,Turley Stewart²,Hol Wim G. J.²,McColm Sarah¹,Gura Colby¹,DiMaio Frank²,Korotkov Konstantin V.²³^ORCID,Sandkvist Maria¹

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

2. Department of Biochemistry, University of Washington, Seattle, Washington, USA

3. Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA

Abstract

Genome-wide transposon mutagenesis has identified the genes encoding the T2SS in Vibrio cholerae as essential for viability, but the reason for this is unclear. Mutants with deletions or insertions in these genes can be isolated, suggesting that they have acquired secondary mutations that suppress their growth defect.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01125-20

Reference70 articles.

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