Mapping Gene-by-Gene Single-Nucleotide Variation in 8,535 Mycobacterium tuberculosis Genomes: a Resource To Support Potential Vaccine and Drug Development

Author:

Papakonstantinou Danai1ORCID,Dunn Steven J.1ORCID,Draper Simon J.2ORCID,Cunningham Adam F.3ORCID,O’Shea Matthew K.3ORCID,McNally Alan1ORCID

Affiliation:

1. Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

2. Jenner Institute, University of Oxford, Oxford, United Kingdom

3. Institute of Immunology and Immunotherapy, MRC Centre of Immune Regulation, University of Birmingham, Birmingham, United Kingdom

Abstract

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis . In the first half of the 20th century, the discovery of the Mycobacterium bovis BCG vaccine and antituberculous drugs heralded a new era in the control of TB.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

University of Birmingham

Wellcome

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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