Toxoplasma gondii Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells-Reference-Cited by-同舟云学术

Toxoplasma gondii Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells

Published:2021-06-30 Issue:3 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Huynh My-Hang¹,Roiko Marijo S.¹^ORCID,Gomes Angelica O.¹,Schinke Ellyn N.¹,Schultz Aric J.¹,Agrawal Swati¹,Oellig Christine A.²,Sexton Travis R.³,Beauchamp Jessica M.¹,Laliberté Julie¹,Sivaraman Komagal Kannan²,Hersh Louis B.⁴,McGowan Sheena²,Carruthers Vern B.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

2. Infection and Immunity Program, Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

3. Department of Cardiology, University of Kentucky, Lexington, Kentucky, USA

4. Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, USA

Abstract

After replicating within infected host cells, the single-celled parasite Toxoplasma gondii must rupture out of such cells in a process termed egress. Although it is known that T. gondii egress is an active event that involves disruption of host-derived membranes surrounding the parasite, very few proteins that are released by the parasite are known to facilitate egress.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00444-21

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