Combination of 2- <i>tert</i> -Butyl-1,4-Benzoquinone (TBQ) and ZnO Nanoparticles, a New Strategy To Inhibit Biofilm Formation and Virulence Factors of Chromobacterium violaceum-Reference-Cited by-同舟云学术

Combination of 2- tert -Butyl-1,4-Benzoquinone (TBQ) and ZnO Nanoparticles, a New Strategy To Inhibit Biofilm Formation and Virulence Factors of Chromobacterium violaceum

Published:2023-02-21 Issue:1 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Liu Junsheng¹²,Chang Zengyan¹³,Chang Xiaosa³,Li Junjian²,Glebe Ulrich⁴⁵,Jia Ai-Qun¹²^ORCID

Affiliation:

1. Key Laboratory of Tropical Biological Resources of Ministry of Education, One Health Institute, Hainan University, Haikou, China

2. School of Pharmaceutical Sciences, Hainan University, Haikou, China

3. School of Pharmaceutical Sciences, Wuhan University, Wuhan, China

4. Institute of Chemistry, University of Potsdam, Potsdam-Golm, Germany

5. Fraunhofer Institute for Applied Polymer Research IAP, Potsdam-Golm, Germany

Abstract

The combination of ZnO-NPs and TBQ (ZnO-TBQ) can compete with the inducer N -decanoyl-homoserine lactone (C 10 -HSL) by binding to CviR and downregulate genes related to the CviI/CviR system to interrupt the QS system of C. violaceum ATCC 12472. The downstream genes responding to cviR were also downregulated so that virulence factors and biofilm formation were inhibited.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hainan Province

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00597-22

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