Control of Human Anelloviruses by Cytosine to Uracil Genome Editing-Reference-Cited by-同舟云学术

Control of Human Anelloviruses by Cytosine to Uracil Genome Editing

Published:2022-12-21 Issue:6 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Timmerman Anne L.¹²^ORCID,Kaczorowska Joanna¹²^ORCID,Deijs Martin¹²,Bakker Margreet¹²,van der Hoek Lia¹²^ORCID

Affiliation:

1. Amsterdam UMC, University of Amsterdam, Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam, The Netherlands

2. Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

Abstract

Despite significant attention on anellovirus research, the interaction between the anellovirus virome and the human host remains unknown. We show the dynamics of APOBEC3-mediated cytidine deaminase activity on anelloviruses during a 30-year period of chronic infection and postulate that this antiviral mechanism controls anelloviruses. These results expand our knowledge of anellovirus-host interactions, which may be important for the design of gene therapies.

Funder

European Union's Horizon 2020 research and Innovation Programme under Marie Sklodowska-Curie Actions

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00506-22

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