Machine Learning of Bacterial Transcriptomes Reveals Responses Underlying Differential Antibiotic Susceptibility

Author:

Sastry Anand V.1,Dillon Nicholas234ORCID,Anand Amitesh1,Poudel Saugat1,Hefner Ying1,Xu Sibei1,Szubin Richard1,Feist Adam M.15,Nizet Victor23,Palsson Bernhard125ORCID

Affiliation:

1. Department of Bioengineering, University of California—San Diego, La Jolla, California, USA

2. Department of Pediatrics, University of California—San Diego, La Jolla, California, USA

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California—San Diego, La Jolla, California, USA

4. Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, USA

5. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark

Abstract

Antibiotic resistance is an imminent threat to global health. Patient treatment regimens are often selected based on results from standardized antibiotic susceptibility testing (AST) in the clinical microbiology lab, but these in vitro tests frequently misclassify drug effectiveness due to their poor resemblance to actual host conditions.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Novo Nordisk Fonden

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3