Recent Vibrio cholerae O1 Epidemic Strains Are Unable To Replicate CTXΦ Prophage Genome-Reference-Cited by-同舟云学术

Recent Vibrio cholerae O1 Epidemic Strains Are Unable To Replicate CTXΦ Prophage Genome

Published:2021-06-09 Issue: Volume: Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Ochi Kaoru¹,Mizuno Tamaki²,Samanta Prosenjit³,Mukhopadhyay Asish K.³,Miyoshi Shin-ichi²,Imamura Daisuke¹^ORCID

Affiliation:

1. Department of Frontier Bioscience, Hosei University, Koganei, Tokyo, Japan

2. Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

3. Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata, India

Abstract

Cholera is an acute diarrheal disease caused by pathogenic strains of V. cholerae generated by lysogenization of the filamentous cholera toxin phage CTXΦ. The analysis revealed that recent isolates possessed altered CTXΦ prophage array of prototype El Tor strain and were defective in replicating the CTXΦ genome.

Funder

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00337-21

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