Comprehensive Identification of Fim-Mediated Inversions in Uropathogenic Escherichia coli with Structural Variation Detection Using Relative Entropy

Author:

Russell Colin W.1,Sukumaran Rashmi1,Liow Lu Ting1,Periaswamy Balamurugan12,Rafee Shazmina1,Chee Yuemin C.1,Chen Swaine L.13ORCID

Affiliation:

1. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

2. GERMS platform, Genome Institute of Singapore, Singapore

3. Infectious Disease Group, Genome Institute of Singapore, Singapore

Abstract

UTI is a common ailment that affects more than half of all women during their lifetime. The leading cause of UTIs is UPEC, which relies on type 1 pili to colonize and persist within the bladder during infection. The regulation of type 1 pili is remarkable for an epigenetic mechanism in which a section of DNA containing a promoter is inverted. The inversion mechanism relies on what are thought to be dedicated recombinase genes; however, the full repertoire for these recombinases is not known. We show here that there are no additional targets beyond those already identified for the recombinases in the entire genome of two UPEC strains, arguing that type 1 pilus expression itself is the driving evolutionary force for the presence of these recombinase genes. This further suggests that targeting the type 1 pilus is a rational alternative nonantibiotic strategy for the treatment of UTI.

Funder

MOH | National Medical Research Council

National Research Foundation Singapore

Genome Institute of Singapore

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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