Genomic Characterization of Skin and Soft Tissue Streptococcus pyogenes Isolates from a Low-Income and a High-Income Setting-Reference-Cited by-同舟云学术

Genomic Characterization of Skin and Soft Tissue Streptococcus pyogenes Isolates from a Low-Income and a High-Income Setting

Published:2023-02-21 Issue:1 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Bah Saikou Y.¹²,Keeley Alexander J.³,Armitage Edwin P.²,Khalid Henna¹,Chaudhuri Roy R.¹,Senghore Elina²,Manneh Jarra²,Tilley Lisa⁴,Marks Michael⁵⁶^ORCID,Darboe Saffiatou²^ORCID,Sesay Abdul K.²,de Silva Thushan I.³²,Turner Claire E.¹^ORCID,Erhart Annette,Smeesters Pierre R.,Antonio Martin,Jabang Sona,Kampmann Beate,Roca Anna,Cox Isatou Jagne,Tiencheu Peggy-Estelle,Mackenzie Grant

Affiliation:

1. School of Biosciences, The Florey Institute, University of Sheffield, Sheffield, United Kingdom

2. The Medical Research Council, The Gambia, London School of Hygiene and Tropical Medicine, Serekunda, The Gambia

3. Department of Infection, Immunity & Cardiovascular Disease, The Florey Institute, University of Sheffield Medical School, Sheffield, United Kingdom

4. Department of Microbiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

5. Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

6. Hospital for Tropical Diseases, London, United Kingdom

Abstract

The global burden of rheumatic heart disease (RHD) has triggered a World Health Organization response to drive forward development of a vaccine against the causative human pathogen Streptococcus pyogenes . This burden stems primarily from low- and middle-income settings where there are high levels of S. pyogenes skin and soft tissue infections, which can lead to RHD.

Funder

Global Challenges Research Fund

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00469-22

Reference56 articles.

1. Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

2. Global, Regional, and National Burden of Rheumatic Heart Disease, 1990–2015