Serum IgM Glycosylation Associated with Tuberculosis Infection in Mice-Reference-Cited by-同舟云学术

Serum IgM Glycosylation Associated with Tuberculosis Infection in Mice

Published:2019-04-24 Issue:2 Volume:4 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Kumagai Tadahiro¹,Palacios Ainhoa²,Casadevall Arturo³^ORCID,García M. Jesús⁴,Toro Carlos⁵,Tiemeyer Michael¹,Prados-Rosales Rafael²⁴⁶^ORCID

Affiliation:

1. Complex Carbohydrate Research Center, The University of Georgia, Athens, Georgia, USA

2. CIC bioGUNE, Derio, Bizkaia, Spain

3. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

4. Department of Preventive Medicine, Public Health and Microbiology, Autonomous University of Madrid, Madrid, Spain

5. Service of Microbiology, Hospital Universitario La Paz, IdiPaz, Madrid, Spain

6. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

Abstract

We demonstrate that M. tuberculosis infection influenced host protein glycosylation in a mouse model. The mechanism by which infection modifies glycans in serum proteins is not understood. Investigation of the regulation of such modifications by M. tuberculosis opens a new field that could lead to the discovery of novel biomarkers. Validation of such findings in human samples will reveal the clinical relevance of these findings.

Funder

HHS | National Institutes of Health

Ministerio de Ciencia, Innovación y Universidades

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00684-18

Reference32 articles.

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2. Cell surface protein glycosylation in cancer