First IncHI2 Plasmid Carrying mcr-9.1 , bla VIM-1 , and Double Copies of bla KPC-3 in a Multidrug-Resistant Escherichia coli Human Isolate-Reference-Cited by-同舟云学术

First IncHI2 Plasmid Carrying mcr-9.1 , bla VIM-1 , and Double Copies of bla KPC-3 in a Multidrug-Resistant Escherichia coli Human Isolate

Published:2021-05-28 Issue: Volume: Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Simoni Serena¹,Mingoia Marina²,Brenciani Andrea²^ORCID,Carelli Maria³,Lleò Maria M.³,Malerba Giovanni⁴,Vignaroli Carla¹^ORCID

Affiliation:

1. Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy

2. Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy

3. Department of Diagnostics and Public Health, University of Verona, Verona, Italy

4. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

Abstract

We report a novel IncHI2 plasmid coharboring bla VIM-1 , two copies of bla KPC-3 and mcr-9.1 resistance genes in a human Escherichia coli of the new serogroup O188. The bla VIM-1 gene was included in a class 1 integron, mcr-9.1 in a cassette bracketed by IS 903 and ΔIS1R, and bla KPC-3 in two copies within a new composite Tn 4401 -like transposon. The emergence of carbapenem and colistin resistance genes in a single plasmid is of great concern for upcoming clinical therapies.

Funder

Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00302-21

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