Eukaryotic Initiation Factor 2α Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens-Reference-Cited by-同舟云学术

Eukaryotic Initiation Factor 2α Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens

Published:2022-06-29 Issue:3 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Walters Heather A.¹²,Welter Brenda H.¹²,Moss Harrison C.¹²,Villano Martha A.¹²,Orobio-Hurtado Ronny¹²,Sullivan William J.³⁴^ORCID,Temesvari Lesly A.¹²^ORCID

Affiliation:

1. Department of Biological Sciences, Clemson University, Clemson, South Carolina, USA

2. Eukaryotic Pathogens Innovation Center (EPIC), Clemson University, Clemson, South Carolina, USA

3. Department of Pharmacology and Toxicology, Indiana University School of Medicine Indianapolis, Indiana, USA

4. Department of Microbiology and Immunology, Indiana University School of Medicine Indianapolis, Indiana, USA

Abstract

Entamoeba histolytica is a human pathogen that causes dysentery and affects millions of people worldwide. This parasite possesses a two-stage life cycle: an environmentally stable cyst and the pathogenic trophozoite.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00131-22

Reference45 articles.

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3. Amebic colitis: New insights into pathogenesis and treatment

4. Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species

5. Phosphorylation of eukaryotic initiation factor-2α in response to endoplasmic reticulum and nitrosative stress in the human protozoan parasite, Entamoeba histolytica

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