Muribaculaceae Genomes Assembled from Metagenomes Suggest Genetic Drivers of Differential Response to Acarbose Treatment in Mice-Reference-Cited by-同舟云学术

Muribaculaceae Genomes Assembled from Metagenomes Suggest Genetic Drivers of Differential Response to Acarbose Treatment in Mice

Published:2021-12-22 Issue:6 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Smith Byron J.¹^ORCID,Miller Richard A.²^ORCID,Schmidt Thomas M.³⁴^ORCID

Affiliation:

1. The Gladstone Institute of Data Science & Biotechnology, San Francisco, California, USA

2. Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, Michigan, USA

3. Department of Ecology & Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA

4. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

Abstract

The drug acarbose is used to treat diabetes by preventing the breakdown of starch in the small intestine, resulting in dramatic changes in the abundance of some members of the gut microbiome and its fermentation products. In mice, several of the bacteria that respond most positively are classified in the family Muribaculaceae , members of which produce propionate as a primary fermentation product.

Funder

Glenn Foundation for Medical Research

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00851-21

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