Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients-Reference-Cited by-同舟云学术

Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Gomez-Simmonds Angela¹^ORCID,Annavajhala Medini K.¹^ORCID,Nunez Maria Patricia²,Macesic Nenad³⁴,Park Heekuk¹,Uhlemann Anne-Catrin¹^ORCID

Affiliation:

1. Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA

2. Department of Microbiology & Immunology, Columbia University, New York, New York, USA

3. Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia

4. Centre to Impact AMR, Monash University, Melbourne, Victoria, Australia

Abstract

Liver transplant (LT) recipients have high rates of Clostridioides difficile infection (CDI), which has been associated with poor outcomes, including graft-related complications and mortality, in prior studies. Susceptibility to CDI is known to increase following perturbations in intestinal commensal bacteria that enable germination of C. difficile spores and bacterial overgrowth.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Irving Institute for Clinical and Translational Research

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00361-22

Reference36 articles.

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5. Incidence Rates and Risk Factors of Clostridioides difficile Infection in Solid Organ and Hematopoietic Stem Cell Transplant Recipients

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