The Molecular Epidemiology of Prevalent Klebsiella pneumoniae Strains and Humoral Antibody Responses against Carbapenem-Resistant K. pneumoniae Infections among Pediatric Patients in Shanghai-Reference-Cited by-同舟云学术

The Molecular Epidemiology of Prevalent Klebsiella pneumoniae Strains and Humoral Antibody Responses against Carbapenem-Resistant K. pneumoniae Infections among Pediatric Patients in Shanghai

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5042
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language:en
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Author:

Wang Jie¹²,Ma Ruijing¹,Pan Fen²,Wu Yongqin¹,Pan Yuqing¹,Liu Yanan²,Yu Fangyuan²,Yu Jingran¹,Lun Heyuan¹,Shi Yingying²,Zhang Hong²,He Ping¹^ORCID

Affiliation:

1. Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2. Department of Clinical Laboratory, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

Abstract

The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains resistant to numerous antibiotics and the limited therapeutic options available have become an urgent health threat to the immunocompromised pediatric population. Vaccines and antibodies, especially those targeting capsular polysaccharides, may be novel and effective prevention and treatment options.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanghai

Shanghai Municipal Key Clinical Specialty

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00271-22

Reference50 articles.

1. Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms