Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of <i>Enterobacterales</i> and Pseudomonas aeruginosa in Latin American Hospitals-Reference-Cited by-同舟云学术

Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals

Published:2023-04-20 Issue:2 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Mojica María Fernanda¹²³⁴^ORCID,De La Cadena Elsa¹,García-Betancur Juan Carlos¹,Porras Jessica¹,Novoa-Caicedo Isabella¹,Páez-Zamora Laura¹,Pallares Christian¹,Appel Tobias Manuel¹,Radice Marcela A.⁵,Castañeda-Méndez Paulo⁶⁷,Gales Ana C.⁸,Munita José M.⁹,Villegas María Virginia¹

Affiliation:

1. Grupo de Investigación en Resistencia Antimicrobiana y Epidemiología Hospitalaria, Universidad El Bosque, Bogotá, Colombia

2. Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

3. Veterans Affairs Medical Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Case Western Reserve University-Cleveland, Cleveland, Ohio, USA

4. Research Service, VA Northeast Ohio Healthcare System, Cleveland, Ohio, USA

5. Departamento de Microbiología, Inmunología, Biotecnología y Genética, Cátedra de Microbiología, Universidad de Buenos Aires—CONICET, Buenos Aires, Argentina

6. Department of Infectious Diseases, Hospital Médica Sur, Ciudad de México, México

7. Department of Infectious Diseases, Hospital San Angel Inn Universidad, Ciudad de México, México

8. Department of Internal Medicine, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil

9. Genomics and Resistant Microbes (GeRM) Group, Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile

Abstract

In this manuscript, we determine the molecular mechanisms of ceftazidime-avibactam resistance in Enterobacterales and P. aeruginosa isolates from five Latin American countries. Our results reveal a low rate of resistance to ceftazidime-avibactam among Enterobacterales ; in contrast, resistance in P. aeruginosa has proven to be more complex, as it might involve multiple known and possibly unknown resistance mechanisms.

Funder

Pfizer

Universidad El Bosque

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00651-22

Reference51 articles.

1. Resistance to ceftazidime–avibactam and underlying mechanisms

2. The increasing threat of Pseudomonas aeruginosa high-risk clones