Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis-Reference-Cited by-同舟云学术

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis

Published:2021-02-24 Issue:1 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Ferrarini Mariana Galvão¹^ORCID,Nisimura Lindice Mitie²,Girard Richard Marcel Bruno Moreira³,Alencar Mayke Bezerra³,Fragoso Mariana Sayuri Ishikawa²,Araújo-Silva Carlla Assis⁴⁵,Veiga Alan de Almeida²,Abud Ana Paula Ressetti²,Nardelli Sheila Cristina²,Vommaro Rossiane C.⁴⁵,Silber Ariel Mariano³^ORCID,France-Sagot Marie¹⁶,Ávila Andréa Rodrigues²^ORCID

Affiliation:

1. Laboratoire de Biométrie et Biologie Évolutive, UMR 5558, CNRS, Université de Lyon 1, Villeurbanne, France

2. Laboratório de Pesquisa em Apicomplexa, Instituto Carlos Chagas, Fiocruz, Paraná, Brazil

3. Laboratory of Biochemistry of Tryps, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil

4. Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

5. Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagens, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

6. INRIA Grenoble Rhône-Alpes, Montbonnot-Saint-Martin, France

Abstract

Currently, the drugs used for toxoplasmosis have severe toxicity to human cells, and the treatment still lacks effective and safer alternatives. The search for novel drug targets is timely.

Funder

Fundacao Araucaria

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Fundação Oswaldo Cruz

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01002-20

Reference98 articles.