Fecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile-Reference-Cited by-同舟云学术

Fecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile

Published:2021-10-27 Issue:5 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Jan N.¹^ORCID,Hays R. A.²,Oakland D. N.¹,Kumar P.³,Ramakrishnan G.¹,Behm B. W.²,Petri W. A.¹⁴⁵^ORCID,Marie C.¹^ORCID

Affiliation:

1. Department of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA

2. Department of Medicine, Gastroenterology & Hepatology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

3. Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, Virginia, USA

4. Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

5. Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

Abstract

Fecal microbiota transplantation (FMT) is an effective treatment for C. difficile infection for most patients; however, introducing a complex mixture of microbes also has had unintended consequences for some patients. Attempts to create a standardized probiotic therapeutic that recapitulates the efficacy of FMT have been unsuccessful to date.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00669-21

Reference72 articles.

1. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

2. Clinical update for the diagnosis and treatment ofClostridium difficileinfection