Affiliation:
1. LSU Health Sciences Center New Orleans, New Orleans, Louisiana, USA
2. Loyola University New Orleans, New Orleans, Louisiana, USA
Abstract
In the last decade,
Candida auris
has emerged globally as a multidrug‐resistant fungal pathogen. Although
C. auris
was initially isolated from the external ear canal, it can cause outbreaks of invasive infections with very high mortality and comorbidities. Recent reports highlight the ongoing challenges due to organism misidentification, high rates of multifungal drug resistance, and unacceptably high patient mortality. The assessment of
C. auris
virulence in a specific genetic deficiency mouse model of invasive
C. auris
infection in this study contributes to the little knowledge of host defense to
C. auris
infection, which holds promise as a model for investigating the pathogenesis of
C. auris
invasive infection, exploring the immune responses elicited by the fungus, evaluating the possible induction of immunity to the infection, and targeting candidates for an antifungal vaccine.
Funder
HHS | National Institutes of Health
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
39 articles.
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