Comparative Study of the Susceptibility to Oxidative Stress between Two Types of Mycobacterium bovis BCG Tokyo 172-Reference-Cited by-同舟云学术

Comparative Study of the Susceptibility to Oxidative Stress between Two Types of Mycobacterium bovis BCG Tokyo 172

Published:2021-04-28 Issue:2 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Taniguchi Keiichi¹,Hayashi Daisuke²,Yasuda Naomi³,Nakayama Mao³,Yazawa Kaori³,Ogawa Shouta¹,Miyatake Yuji¹,Suda Saki¹,Tomita Haruka¹,Tokuda Miki¹,Itoh Saotomo¹,Maeyama Jun-ichi⁴,Ohara Naoya⁵,Yamamoto Saburo²,Hida Shigeaki¹,Onozaki Kikuo¹,Takii Takemasa¹³^ORCID

Affiliation:

1. Department of Molecular Health Sciences, Graduated School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Aichi, Japan

2. Japan BCG Laboratory, Kiyose, Tokyo, Japan

3. Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Tokyo, Japan

4. Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan

5. Department of Oral Microbiology, Graduated School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Abstract

This study revealed the difference of in vivo and in vitro antioxidative stress properties of BCG Tokyo 172 types I and II as one of the bacteriological characteristics. In particular, the bacilli exhibited differences in catalase/peroxidase activity, which could explain their different protective effects against infection.

Funder

Japan Health Foundation

Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00111-21

Reference56 articles.

1. Report of an International collaborative study to establish the first WHO reference reagents for BCG vaccines of three different sub-strains

2. Comparable studies of immunostimulating activitiesin vitroamongMycobacterium bovisbacillus Calmette-Guérin (BCG) substrains

3. Biochemical characteristics amongMycobacterium bovisBCG substrains

4. Redox homeostasis in mycobacteria: the key to tuberculosis control?

5. Virulence and Resistance to Superoxide, Low pH and Hydrogen Peroxide among Strains of Mycobacterium tuberculosis