Clinical Candida albicans Vaginal Isolates and a Laboratory Strain Show Divergent Behaviors during Macrophage Interactions-Reference-Cited by-同舟云学术

Clinical Candida albicans Vaginal Isolates and a Laboratory Strain Show Divergent Behaviors during Macrophage Interactions

Published:2020-08-26 Issue:4 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Gerwien Franziska¹,Dunker Christine²,Brandt Philipp¹,Garbe Enrico¹,Jacobsen Ilse D.²,Vylkova Slavena¹^ORCID

Affiliation:

1. Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell Institute, Jena, Germany

2. Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell Institute, Jena, Germany

Abstract

Vulvovaginal candidiasis is one of the most common fungal infections in humans with Candida albicans as the major causative agent. This study is the first to compare clinical vaginal isolates of defined patient groups in their interaction with macrophages, highlighting the vastly different outcomes in comparison to a laboratory strain using commonly applied virulence-determining assays.

Funder

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00393-20

Reference21 articles.

1. New Insights in Candida albicans Innate Immunity at the Mucosa: Toxins, Epithelium, Metabolism, and Beyond

2. Vulvovaginal Candidiasis: A Current Understanding and Burning Questions