Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation

Author:

Cai Zhendong12,Du Wenlong1,Liu Lianhong1,Pan Daodong2,Lu Ling1ORCID

Affiliation:

1. Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China

2. Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang Province, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo, China

Abstract

Copper is an essential cofactor of enzymes during a variety of biochemical processes. Therefore, Cu acquisition plays critical roles in cell survival and proliferation, especially during Cu starvation. Knowledge of the key motif(s) by which the low-Cu-responsive transcription factor Mac1 senses Cu is important for understanding how Cu uptake is controlled. Findings in this study demonstrated that the Cu fist motif, but not Cys-rich motifs, is essential for Mac1-mediated Cu uptake in Aspergillus . In addition, Cu transporters CtrA2 and CtrC are both required for Mac1-mediated Cu uptake during Cu starvation in A. nidulans , indicating that species-specific machinery exists for Cu acquisition in Aspergillus .

Funder

Program for Jiangsu Excellent Scientific and Technological Innovation Team

Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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