Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species

Author:

Auerbach Ashley A.123ORCID,Becker Jordan T.234ORCID,Moraes Sofia N.23,Moghadasi Seyed Arad23,Duda Jolene M.3,Salamango Daniel J.235,Harris Reuben S.16ORCID

Affiliation:

1. Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, USA

2. Institute for Molecular Virology, University of Minnesota – Twin Cities, Minneapolis, Minnesota, USA

3. Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota – Twin Cities, Minneapolis, Minnesota, USA

4. Department of Microbiology and Immunology, University of Minnesota – Twin Cities, Minneapolis, Minnesota, USA

5. Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA

6. Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas, USA

Abstract

APOBEC3 enzymes are single-stranded DNA cytosine-to-uracil deaminases with beneficial roles in antiviral immunity and detrimental roles in cancer mutagenesis. Regarding viral infection, all seven human APOBEC3 enzymes have overlapping roles in restricting virus types that require DNA for replication, including EBV, HIV, human papillomavirus (HPV), and human T-cell leukemia virus (HTLV).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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