Collateral Sensitivity to β-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes-Reference-Cited by-同舟云学术

Collateral Sensitivity to β-Lactam Drugs in Drug-Resistant Tuberculosis Is Driven by the Transcriptional Wiring of BlaI Operon Genes

Published:2021-05-28 Issue: Volume: Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Trigos A. S.¹²^ORCID,Goudey B. W.³⁴,Bedő J.³⁵,Conway T. C.¹,Faux N. G.⁶⁷,Wyres K. L.⁸^ORCID

Affiliation:

1. Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

2. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia

3. The School of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia

4. Centre For Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia

5. Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

6. Melbourne Data Analytics Platform, The University of Melbourne, North Melbourne, Victoria, Australia

7. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia

8. Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Victoria, Australia

Abstract

Tuberculosis remains a significant cause of global mortality, with strains resistant to classical drug treatment considered a major health concern by the World Health Organization. Challenging treatment regimens and difficulty accessing drugs in low-income communities have led to a high prevalence of strains resistant to multiple drugs, making the development of alternative therapies a priority.

Funder

Australian Computer Society

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00245-21

Reference81 articles.

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5. World Health Organization. 2020. Global tuberculosis report. World Health Organization, Geneva, Switzerland.

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1. In vitro activity of new combinations of β-lactam and β-lactamase inhibitors against the Mycobacterium tuberculosis complex;Microbiology Spectrum;2023-10-17

2. Transcriptional regulation and drug resistance in Mycobacterium tuberculosis;Frontiers in Cellular and Infection Microbiology;2022-09-02