CD8 + Cytotoxic-T-Lymphocyte Breadth Could Facilitate Early Immune Detection of Immunodeficiency Virus-Derived Epitopes with Limited Expression Levels-Reference-Cited by-同舟云学术

CD8 + Cytotoxic-T-Lymphocyte Breadth Could Facilitate Early Immune Detection of Immunodeficiency Virus-Derived Epitopes with Limited Expression Levels

Published:2019-02-27 Issue:1 Volume:4 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Tsukamoto Tetsuo¹^ORCID,Yamamoto Hiroyuki¹,Matano Tetsuro²³

Affiliation:

1. Department of Immunology, Kindai University Faculty of Medicine, Osaka, Japan

2. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

3. The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Abstract

Cytotoxic-T-lymphocyte (CTL) responses are important to control the replication of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). Accumulating evidence suggests that the ability of a few immunodominant T-cell populations to detect and kill HIV/SIV-infected cells is important in individuals with a protective major histocompatibility complex class I (MHC-I) allele.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00381-18

Reference27 articles.

1. Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 Infection

2. Cytotoxic T Lymphocyte–based Control of Simian Immunodeficiency Virus Replication in a Preclinical AIDS Vaccine Trial

3. Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

4. CD4+T Cell Persistence and Function after Infection Are Maintained by Low-Level Peptide:MHC Class II Presentation

5. Broadening of CD8+ cell responses in vaccine-based simian immunodeficiency virus controllers

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