The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells-Reference-Cited by-同舟云学术

The E2F4/p130 Repressor Complex Cooperates with Oncogenic ΔNp73α To Inhibit Gene Expression in Human Papillomavirus 38 E6/E7-Transformed Keratinocytes and in Cancer Cells

Published:2023-04-20 Issue:2 Volume:8 Page:
ISSN:2379-5042
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Author:

Taverniti Valerio¹,Krynska Hanna¹²,Venuti Assunta¹,Straub Marie-Laure²,Sirand Cécilia¹,Lohmann Eugenie¹,Romero-Medina Maria Carmen¹,Moro Stefano²,Robitaille Alexis¹,Negroni Luc³,Martinez-Zapien Denise²,Masson Murielle²^ORCID,Tommasino Massimo⁴,Zanier Katia²^ORCID

Affiliation:

1. International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France

2. Biotechnology and Cell Signaling (CNRS/Université de Strasbourg, UMR 7242), Ecole Superieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant, Illkirch, France

3. Proteomics platform, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg, Illkirch, France

4. IRCCS Istituto Tumori Giovanni Paolo II of Bari, Bari, Italy

Abstract

The TP53 gene is mutated in about 50% of human cancers. In contrast, the TP63 and TP73 genes are rarely mutated but rather expressed as ΔNp63 and ΔNp73 isoforms in a wide range of malignancies, where they act as p53 antagonists.

Funder

Alsace contre le Cancer

Agence Nationale de la Recherche

Fondation ARC pour la Recherche sur le Cancer

Fondation pour la Recherche Médicale

Institut National de la Santé et de la Recherche Médicale

Ligue Contre le Cancer

Ministero della Salute

‘Institut National du Cancer’

Publisher

American Society for Microbiology

Subject