TgTKL4 Is a Novel Kinase That Plays an Important Role in <i>Toxoplasma</i> Morphology and Fitness-Reference-Cited by-同舟云学术

TgTKL4 Is a Novel Kinase That Plays an Important Role in Toxoplasma Morphology and Fitness

Published:2023-04-20 Issue:2 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Montano Hilary¹,Anandkrishnan Ramu¹²,Carruthers Vern B.³^ORCID,Gaji Rajshekhar Y.¹^ORCID

Affiliation:

1. Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA

2. Department of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, Virginia, USA

3. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

Toxoplasma gondii is a protozoan parasite that can cause life-threatening disease in mammals; hence, identifying key factors required for parasite growth and pathogenesis is important to develop novel therapeutics. In this study, we identified and characterized another member of the newly described TKL family, TgTKL4, a cell cycle-regulated kinase.

Funder

American Heart Association

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00649-22

Reference44 articles.

1. Advances in the life cycle of Toxoplasma gondii

2. Toxoplasmosis: A history of clinical observations