Bioinformatic Mining and Structure-Activity Profiling of Baeyer-Villiger Monooxygenases from Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Bioinformatic Mining and Structure-Activity Profiling of Baeyer-Villiger Monooxygenases from Mycobacterium tuberculosis

Published:2022-04-27 Issue:2 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Tomas Nicolas¹,Leonelli Dimitri¹,Campoy Martin¹,Marthey Sylvain²,Le Nguyen-Hung¹,Rengel David¹,Martin Véronique²,Pál Adrian³,Korduláková Jana³,Eynard Nathalie⁴,Guillet Valérie¹,Mourey Lionel¹,Daffé Mamadou¹,Lemassu Anne¹^ORCID,André Gwenaëlle²^ORCID,Marrakchi Hedia¹^ORCID

Affiliation:

1. Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France

2. MaIAGE, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France

3. Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia

4. LMGM-CBI, UMR 5100, Université de Toulouse, CNRS, UPS, Toulouse, France

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis , is one of the leading causes of death worldwide. The rise in drug resistance highlights the urgent need for innovation in anti-TB drug development.

Funder

Ministry of Higher Education, Research and Innovation

Slovak Research and Development Agency

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00482-21

Reference40 articles.

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2. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis

3. MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against Mycobacterium tuberculosis

4. Activation of the Pro-drug Ethionamide Is Regulated in Mycobacteria

5. Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors

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