Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein-Reference-Cited by-同舟云学术

Structure-Guided Design of a Synthetic Mimic of an Endothelial Protein C Receptor-Binding PfEMP1 Protein

Published:2021-02-24 Issue:1 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Barber Natalie M.¹,Lau Clinton K. Y.¹,Turner Louise²³,Watson Gareth¹,Thrane Susan²³,Lusingu John P. A.⁴,Lavstsen Thomas²³^ORCID,Higgins Matthew K.¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Oxford, Oxford, United Kingdom

2. Centre for Medical Parasitology, Department of Immunology & Microbiology, University of Copenhagen, Copenhagen, Denmark

3. Centre for Medical Parasitology, Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark

4. National Institute for Medical Research, Dar es Salaam, Tanzania

Abstract

Vaccines train our immune systems to generate antibodies which recognize pathogens. Some of these antibodies are highly protective, preventing infection, while others are ineffective.

Funder

Wellcome

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01081-20

Reference40 articles.

1. Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

2. Emerging challenges in understanding trypanosome antigenic variation

3. Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families

4. Malaria's deadly grip: cytoadhesion ofPlasmodium falciparum-infected erythrocytes

5. The Role of Variant Surface Antigens on Malaria-infected Red Blood Cells

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1. PfEMP1 and var genes – Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity;Advances in Parasitology;2024

2. Structural and genomic analysis of single nucleotide polymorphisms in human host factor endothelial protein C receptor (EPCR) reveals complex interplay with malaria parasites;Infection, Genetics and Evolution;2023-06

3. Protein scaffolds: antibody alternatives for cancer diagnosis and therapy;RSC Chemical Biology;2022