A Predicted Mannoprotein Participates in Cryptococcus gattii Capsular Structure-Reference-Cited by-同舟云学术

A Predicted Mannoprotein Participates in Cryptococcus gattii Capsular Structure

Published:2018-04-25 Issue:2 Volume:3 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Reuwsaat Julia Catarina Vieira¹,Motta Heryk¹,Garcia Ane Wichine Acosta¹,Vasconcelos Carolina Bettker¹,Marques Bárbara Machado¹,Oliveira Natália Kronbauer¹,Rodrigues Jéssica²,Ferrareze Patrícia Aline Gröhns¹,Frases Susana³,Lopes William¹^ORCID,Barcellos Vanessa Abreu¹,Squizani Eamim Daidrê¹,Horta Jorge André⁴,Schrank Augusto¹⁵,Rodrigues Marcio Lourenço²⁶^ORCID,Staats Charley Christian¹⁵,Vainstein Marilene Henning¹⁵,Kmetzsch Lívia¹⁵^ORCID

Affiliation:

1. Laboratório de Fungos de Importância Médica e Biotecnológica, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

2. Laboratório de Biologia Celular de Leveduras Patogênicas, Instituto de Microbiologia Paulo de Goés, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

3. Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

4. Departamento de Biologia e Farmácia, Universidade de Santa Cruz do Sul (UNISC), Programa de Pós-Graduação em Promoção da Saúde, Santa Cruz do Sul, RS, Brazil

5. Departamento de Biologia Molecular e Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

6. Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil

Abstract

Cryptococcus gattii has the ability to escape from the host’s immune system through poorly understood mechanisms and can lead to the death of healthy individuals. The role of mannoproteins in C. gattii pathogenicity is not completely understood. The present work characterized a protein, Kpr1, that is essential for the maintenance of C. gattii main virulence factor, the polysaccharide capsule. Our data contribute to the understanding of the role of Kpr1 in capsule structuring, mainly by modulating the distribution of glucans in C. gattii cell wall.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00023-18

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1. The Biology of the Cryptococcus neoformans Species Complex

2. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis