Regulation of Nitrogen Metabolism by GATA Zinc Finger Transcription Factors in Yarrowia lipolytica-Reference-Cited by-同舟云学术

Regulation of Nitrogen Metabolism by GATA Zinc Finger Transcription Factors in Yarrowia lipolytica

Published:2017-02-22 Issue:1 Volume:2 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Pomraning Kyle R.¹^ORCID,Bredeweg Erin L.²^ORCID,Baker Scott E.²^ORCID

Affiliation:

1. Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, Washington, USA

2. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA

Abstract

Nitrogen source is commonly used to control lipid production in industrial fungi. Here we identified regulators of nitrogen catabolite repression in the oleaginous yeast Y. lipolytica to determine how the nitrogen source regulates lipid metabolism. We show that disruption of both activators and repressors of nitrogen catabolite repression leads to increased lipid accumulation via activation of carbon catabolite repression through an as yet uncharacterized method.

Funder

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00038-17

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