A Critical Analysis of the Scientific and Commercial Rationales for the De Novo Synthesis of Horsepox Virus-Reference-Cited by-同舟云学术

A Critical Analysis of the Scientific and Commercial Rationales for the De Novo Synthesis of Horsepox Virus

Published:2018-04-25 Issue:2 Volume:3 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Koblentz Gregory D.¹

Affiliation:

1. Schar School of Policy and Government, George Mason University, Arlington, Virginia, USA

Abstract

This article evaluates the scientific and commercial rationales for the synthesis of horsepox virus. I find that the claimed benefits of using horsepox virus as a smallpox vaccine rest on a weak scientific foundation and an even weaker business case that this project will lead to a licensed medical countermeasure.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00040-18

Reference59 articles.

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2. Construction of an infectious horsepox virus vaccine from chemically synthesized DNA fragments

3. Important questions global health and science leaders should be asking in the wake of horsepox synthesis;Inglesby T;The Bifurcated Needle,2017

4. The De Novo Synthesis of Horsepox Virus: Implications for Biosecurity and Recommendations for Preventing the Reemergence of Smallpox

5. Biosecurity Implications for the Synthesis of Horsepox, an Orthopoxvirus

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