Serum-Mediated Cleavage of Bacillus anthracis Protective Antigen Is a Two-Step Process That Involves a Serum Carboxypeptidase-Reference-Cited by-同舟云学术

Serum-Mediated Cleavage of Bacillus anthracis Protective Antigen Is a Two-Step Process That Involves a Serum Carboxypeptidase

Published:2018-06-27 Issue:3 Volume:3 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Goldman David L.¹²³,Nieves Edward⁴,Nakouzi Antonio¹,Rivera Johanna¹,Phyu Ei Ei²,Win Than Htut²,Achkar Jacqueline M.¹⁵,Casadevall Arturo¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Einstein College of Medicine, Bronx, New York, USA

2. Department of Pediatrics, Einstein College of Medicine, Bronx, New York, USA

3. The Children’s Hospital at Montefiore, Bronx, New York, USA

4. Department of Biochemistry, Einstein College of Medicine, Bronx, New York, USA

5. Department of Medicine at the Albert Einstein College of Medicine, Bronx, New York, USA

Abstract

Our findings identify a serum-mediated modification of PA 20 that has not been previously described. These observations further imply that the processing of PA is more complex than currently thought. Additional study is needed to define the contribution of serum processing of PA to the host response and individual susceptibility to anthrax.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00091-18

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