CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge-Reference-Cited by-同舟云学术

CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To Induce Protective Systemic Immunity against Genital Viral Challenge

Published:2021-04-28 Issue:2 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Yan Yan¹,Hu Kai²,Fu Ming²³,Deng Xu²,Luo Sukun²,Tong Lina²,Guan Xinmeng²,He Siyi²,Li Chang²,Jin Wei²,Du Tao²,Zheng Zifeng²³,Zhang Mudan²³,Liu Yalan²,Hu Qinxue²⁴^ORCID

Affiliation:

1. Center of Clinical Laboratory, The Fifth People's Hospital of Wuxi, Affiliated Hospital of Jiangnan University, Wuxi, China

2. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China

3. Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China

4. Institute for Infection and Immunity, St. George’s, University of London, London, United Kingdom

Abstract

An effective HSV-2 vaccine should induce antigen (Ag)-specific immune responses against viral mucosal infection. This study reveals that chemokine CCL19 or CCL28 enhanced HSV-2 glycoprotein D ectodomain (gD-306aa)-induced immune responses against vaginal virus challenge.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00058-21

Reference47 articles.

1. Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012

2. Comparative Efficacy and Immunogenicity of Replication-Defective, Recombinant Glycoprotein, and DNA Vaccines for Herpes Simplex Virus 2 Infections in Mice and Guinea Pigs

3. Seroepidemiology of herpes simplex virus type 2 (HSV2) in HIV infected patients in Kermanshah-Iran;Janbakhash A;Caspian J Intern Med,2012