Tup1 Paralog CgTUP11 Is a Stronger Repressor of Transcription than CgTUP1 in Candida glabrata

Abstract

Due to a whole-genome duplication, many yeast species related to C. glabrata have two copies of the well-characterized TUP1 gene, unlike most Saccharomyces species. This work identifies roles for the paralogs in C. glabrata , highlights the importance of the uncharacterized paralog, called TUP11 , and suggests that the two paralogs have both overlapping and unique functions.