The Membrane Activity of the Amphibian Temporin B Peptide Analog TB_KKG6K Sheds Light on the Mechanism That Kills Candida albicans-Reference-Cited by-同舟云学术

The Membrane Activity of the Amphibian Temporin B Peptide Analog TB_KKG6K Sheds Light on the Mechanism That Kills Candida albicans

Published:2022-10-26 Issue:5 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Kakar Anant¹,Sastré-Velásquez Luis Enrique¹,Hess Michael²,Galgóczy László³⁴,Papp Csaba⁵,Holzknecht Jeanett¹,Romanelli Alessandra⁶,Váradi Györgyi⁷,Malanovic Nermina⁸^ORCID,Marx Florentine¹^ORCID

Affiliation:

1. Biocenter, Institute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria

2. Institute for Histology and Embryology, Medical University of Innsbruck, Innsbruck, Austria

3. Department of Biotechnology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary

4. Institute of Biochemistry, Biological Research Centre, Eötvös Loránd Research Network, Szeged, Hungary

5. Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary

6. Department of Pharmaceutical Sciences, University of Milan, Milan, Italy

7. Department of Medical Chemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary

8. Institute of Molecular Biosciences, Field of Excellence BioHealth, University of Graz, Graz, Austria

Abstract

Fungal infections with the opportunistic human pathogen C. albicans are associated with high mortality rates in immunocompromised patients. This is partly due to the yeast's ability to rapidly develop resistance toward currently available antifungals.

Funder

Austrian Science Fund

Hungarian National Research, Development and Innovation Office

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00290-22

Reference80 articles.

1. An Overview of Fungal Infections

2. Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development

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4. Candida albicans—The Virulence Factors and Clinical Manifestations of Infection

5. Mechanisms of action of antimicrobial peptides ToAP2 and NDBP-5.7 against Candida albicans planktonic and biofilm cells

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