Probiotic Bifidobacteria Mitigate the Deleterious Effects of <i>para</i> -Cresol in a Drosophila melanogaster Toxicity Model-Reference-Cited by-同舟云学术

Probiotic Bifidobacteria Mitigate the Deleterious Effects of para -Cresol in a Drosophila melanogaster Toxicity Model

Published:2022-12-21 Issue:6 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Stuivenberg Gerrit A.¹²^ORCID,Chmiel John A.¹²^ORCID,Akouris Polycronis P.¹²^ORCID,Burton Jeremy P.¹²³^ORCID,Reid Gregor¹²³^ORCID

Affiliation:

1. Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, Ontario, Canada

2. Department of Microbiology and Immunology, Western University, London, Ontario, Canada

3. Department of Surgery, Western University, London, Ontario, Canada

Abstract

Chronic kidney disease (CKD) affects approximately 10% of the global population and has limited treatment options. The accumulation of gut microbiota-derived uremic toxins, such as para -cresol ( p -cresol) and p- cresyl sulfate, is associated with the onset of comorbidities (i.e., atherosclerosis and cognitive disorders) in CKD.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00446-22

Reference76 articles.

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