Interlaboratory Reproducibility of Standardized Hemagglutination Inhibition Assays

Author:

Bibby David C.1ORCID,Savanovic Michael1,Zhang Jinrong1,Torelli Alessandro2,Jeeninga Rienk E.3,Gagnon Luc4,Harris Shannon L.1

Affiliation:

1. Seqirus, Inc., Cambridge, Massachusetts, USA

2. VisMederi srl, Siena, Italy

3. Viroclinics DDL, Rotterdam, The Netherlands

4. Nexelis, Laval, Quebec, Canada

Abstract

Licensure of influenza vaccines relies on the hemagglutination inhibition (HI) assay as the primary method to determine quantitative functional antibody titers. The HI assay is also widely used for influenza virus surveillance, characterization, and epidemiology studies.

Funder

Seqirus, Inc.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference12 articles.

1. Food and Drug Administration. 2007. Guidance for industry: clinical data needed to support the licensure of seasonal inactivated influenza vaccines. US Department of Health and Human Services, Rockville, MD.

2. WHO Global Influenza Surveillance Network. 2011. Manual for the laboratory diagnosis and virological surveillance of influenza. World Health Organization, Geneva, Switzerland.

3. Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay

4. ADSORPTION OF INFLUENZA HEMAGGLUTININS AND VIRUS BY RED BLOOD CELLS

5. Correlates of protection to influenza virus, where do we go from here?

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