Affiliation:
1. St. Louis College of Pharmacy, St. Louis, Missouri, USA
Abstract
Currently, there is very little known about the phenotypic variability within species of
Rhodotorula
strains and the role of their capsule.
Cryptococcus neoformans
has been considered the only encapsulated human fungal pathogen, but as more individuals come to live in states of immunocompromised health, they are more susceptible to fungal infections, including those by
Rhodotorula
.
R. mucilaginosa
species are some of those most commonly associated with clinical infections. We wanted to know if clinical and environmental strains of
R. mucilaginosa
demonstrated disparate capsule phenotypes. With limited antifungal options available and clinical
Rhodotorula
spp. often resistant to common antifungal drugs such as fluconazole, caspofungin (1, 2), and voriconazole (2), a better understanding of the fungal biology could inform the design and use of future antifungal drugs. The generation of an antibody specific to
Rhodotorula
fungi could be a useful diagnostic tool, and this work presents the first mention of such in the literature.
Funder
St. Louis College of Pharmacy, Faculty Researcy Incentive Fund
St. Louis College of Pharmacy, Faculty Research Incentive Fund
Pennsylvania Academy of Sciences
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
5 articles.
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