pmrCAB Recombination Events among Colistin-Susceptible and -Resistant Acinetobacter baumannii Clinical Isolates Belonging to International Clone 7-Reference-Cited by-同舟云学术

pmrCAB Recombination Events among Colistin-Susceptible and -Resistant Acinetobacter baumannii Clinical Isolates Belonging to International Clone 7

Published:2021-12-22 Issue:6 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Nodari Carolina Silva¹²^ORCID,Fuchs Sebastian Alexander³,Xanthopoulou Kyriaki²⁴^ORCID,Cayô Rodrigo¹⁵,Seifert Harald²⁴,Gales Ana Cristina¹,Dilthey Alexander³,Higgins Paul G.²⁴^ORCID

Affiliation:

1. Universidade Federal de São Paulo-UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil

2. Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany

3. Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

4. German Center for Infection Research (DZIF), partner site Bonn-Cologne, Cologne, Germany

5. Universidade Federal de São Paulo (UNIFESP), Laboratório de Bacteriologia e Imunologia (LIB), Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas (DCB), Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF), Diadema, Brazil

Abstract

Colistin resistance rates among Acinetobacter baumannii clinical isolates have increased over the last 20 years. Despite reports of the spread of plasmid-mediated colistin resistance among Enterobacterales , the presence of mcr -type genes in Acinetobacter spp. remains rare, and reduced colistin susceptibility is mainly associated with the acquisition of nonsynonymous mutations in pmrCAB .

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Jürgen Manchot Stiftung

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00746-21

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