Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development-Reference-Cited by-同舟云学术

Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

Published:2019-10-30 Issue:5 Volume:4 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Avci Fikri¹,Berti Francesco²,Dull Peter³,Hennessey John⁴,Pavliak Viliam⁵,Prasad A. Krishna⁶,Vann Willie⁷,Wacker Michael⁸,Marcq Olivier⁹

Affiliation:

1. Department of Biochemistry and Molecular Biology, Center for Molecular Medicine and Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA

2. GSK Vaccines, Siena, Italy

3. Bill and Melinda Gates Foundation, Seattle, Washington, USA

4. Independent Researcher, Lower Gwynedd, Pennsylvania, USA

5. International Vaccines Institute (IVI), Seoul, Republic of Korea

6. Citranvi LLC, Chapel Hill, North Carolina, USA

7. FDA-CBER, Silver Spring, Maryland, USA

8. Wacker Biotech Consulting, Thalwil, Switzerland

9. Sutrovax, Foster City, California, USA

Abstract

Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00520-19

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