Streptococcus suis Encodes Multiple Allelic Variants of a Phase-Variable Type III DNA Methyltransferase, ModS, That Control Distinct Phasevarions

Author:

Tram Greg1,Jen Freda E.-C.1,Phillips Zachary N.1,Timms Jamie1,Husna Asma-Ul1,Jennings Michael P.1ORCID,Blackall Patrick J.2,Atack John M.1ORCID

Affiliation:

1. Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

2. Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St. Lucia, Queensland, Australia

Abstract

Streptococcus suis is a causative agent of meningitis, polyarthritis, and polyserositis in swine, and it is a major cause of zoonotic meningitis in humans. Here, we investigate epigenetic gene regulation in S. suis by multiple phasevarions controlled by the phase-variable type III DNA methyltransferase ModS.

Funder

ARS

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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