Induction of β-Lactamase Activity and Decreased β-Lactam Susceptibility by CO 2 in Clinical Bacterial Isolates-Reference-Cited by-同舟云学术

Induction of β-Lactamase Activity and Decreased β-Lactam Susceptibility by CO 2 in Clinical Bacterial Isolates

Published:2017-08-30 Issue:4 Volume:2 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Mullen Nathan¹,Raposo Hugo¹,Gudis Polyxeni¹,Barker Linsey¹,Humphries Romney M.²,Schmitt Bryan H.³,Relich Ryan F.³,May Meghan¹

Affiliation:

1. Department of Biomedical Sciences, University of New England College of Osteopathic Medicine, Biddeford, Maine, USA

2. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

3. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA

Abstract

β-Lactamase induction and concurrent β-lactam resistance in respiratory tract pathogens as a consequence of growth in a physiologically relevant level of CO 2 are of clinical significance, particularly given the ubiquity of TEM and SHV β-lactamase genes in diverse bacterial pathogens. This is the first report of β-lactamase induction by 5% CO 2 .

Funder

University of New England

UC | University of California, Los Angeles

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00266-17

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