Synergism and Antagonism of Bacterial-Viral Coinfection in the Upper Respiratory Tract

Author:

Manna Sam123ORCID,McAuley Julie3,Jacobson Jonathan1,Nguyen Cattram D.12,Ullah Md. Ashik4,Sebina Ismail4,Williamson Victoria1,Mulholland E. Kim125,Wijburg Odilia3,Phipps Simon4,Satzke Catherine123

Affiliation:

1. Infection and Immunity, Murdoch Children’s Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia

2. Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia

3. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

4. Respiratory Immunology Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia

5. Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom

Abstract

Respiratory bacterial-viral coinfections (such as pneumococci and influenza virus) are often synergistic, resulting in enhanced disease severity. Although colonization of the nasopharynx is the precursor to disease and transmission, little is known about bacterial-viral interactions that occur within this niche.

Funder

Jack Brockhoff Foundation

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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