Mapping the Role of AcrAB-TolC Efflux Pumps in the Evolution of Antibiotic Resistance Reveals Near-MIC Treatments Facilitate Resistance Acquisition-Reference-Cited by-同舟云学术

Mapping the Role of AcrAB-TolC Efflux Pumps in the Evolution of Antibiotic Resistance Reveals Near-MIC Treatments Facilitate Resistance Acquisition

Published:2020-12-23 Issue:6 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Langevin Ariel M.¹²,El Meouche Imane¹²,Dunlop Mary J.¹²^ORCID

Affiliation:

1. Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA

2. Biological Design Center, Boston, Massachusetts, USA

Abstract

Combatting the rise of antibiotic resistance is a significant challenge. Efflux pumps are an important contributor to drug resistance; they exist across many cell types and can export numerous classes of antibiotics.

Funder

HHS | National Institutes of Health

National Science Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.01056-20

Reference68 articles.

1. Optimized arylomycins are a new class of Gram-negative antibiotics

2. New antibiotics target the outer membrane of bacteria

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5. Chimeric peptidomimetic antibiotics against Gram-negative bacteria

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