Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion-Reference-Cited by-同舟云学术

Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion

Published:2022-08-31 Issue:4 Volume:7 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Gencheva Stefaniya¹,Dersch Simon²,Surmann Kristin³,Wernet Mathias¹,Antelo Luis¹⁴,Hammer Elke³,Graumann Peter L.²^ORCID,Hellmann Nadja⁵,Unden Gottfried¹^ORCID

Affiliation:

1. Institute for Molecular Physiology; Microbiology and Biotechnology, Johannes Gutenberg-University, Mainz, Germany

2. Department of Chemistry, and Centre for Synthetic Microbiology, SYNMIKRO, Philipps-University Marburg, Marburg

3. Department of Functional Genomics, Center for Functional Genomics of Microbes, University Medicine Greifswald, Greifswald, Germany

4. IBWF gGmbH, Institute for Biotechnology and Drug Research, Mainz, Germany

5. Department of Chemistry, Biochemistry, Johannes Gutenberg-University, Mainz, Germany

Abstract

Complex formation of membrane-bound sensor kinases with the response regulators represents an inherent step of signaling from the membrane to the promoters on the DNA. In the C4-dicarboxylate-sensing DcuS-DcuR two-component system, complex formation is strengthened by activation (phosphorylation) in vitro and in vivo , with trapping of the response regulator DcuR at the membrane.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00235-22

Reference58 articles.

1. Bacterial Sensor Kinases: Diversity in the Recognition of Environmental Signals

2. Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases

3. The Histidine Protein Kinase Superfamily

4. How important is the phosphatase activity of sensor kinases?

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dynamics of cell wall-binding proteins at a single molecule level: B. subtilis autolysins show different kinds of motion;Molecular Biology of the Cell;2024-04-01

2. A signaling complex of adenylate cyclase CyaC of Sinorhizobium meliloti with cAMP and the transcriptional regulators Clr and CycR;BMC Microbiology;2023-08-26

3. Fumarate, a central electron acceptor for Enterobacteriaceae beyond fumarate respiration and energy conservation;Advances in Microbial Physiology;2023