MntC-Dependent Manganese Transport Is Essential for Staphylococcus aureus Oxidative Stress Resistance and Virulence-Reference-Cited by-同舟云学术

MntC-Dependent Manganese Transport Is Essential for Staphylococcus aureus Oxidative Stress Resistance and Virulence

Published:2018-08-29 Issue:4 Volume:3 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Handke Luke D.¹,Gribenko Alexey V.¹,Timofeyeva Yekaterina¹,Scully Ingrid L.¹,Anderson Annaliesa S.¹

Affiliation:

1. Pfizer Vaccine Research and Development, Pearl River, New York, USA

Abstract

Work outlined in this report demonstrated that MntC-dependent manganese transport is required for S. aureus virulence. These study results support the model that MntC-specific antibodies elicited by a vaccine have the potential to disrupt S. aureus manganese transport and thus abrogate to its virulence.

Funder

Pfizer

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00336-18

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